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Studies have shown that MR diet can affect methionine level, sulfur metabolism, nucleotide metabolism, one-carbon metabolism, and DNA methylation, depending on S-adenosylmethionine (SAM) in various tumors, then significantly increasing tumor cell death and delaying the multiple tumors progression and metastasis rate [233,234,235]

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Lateral septum adenosine A(2A) receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula